PROBIOTICS

Probiotics are live microorganisms with well-documented immune-supporting properties and health benefits¹.*

There are 100 trillion good bacteria inside our digestive tract, which support several important metabolic and physiological functions of the body^2-4.* These microorganisms are involved in the maturation of the immune system in early childhood, and their colonization of our intestines continues throughout our lives to form the each of our individual intestinal microbiota.

Probiotic bacteria are crucial for healthy digestion, maintenance of intestinal lining, and support of normal intestinal motility⁵.* They participate in the detoxification process and in immune health support².* There are two main groups of probiotics: Lactobacillus and Bifidobacterium, each with microorganisms that have different beneficial properties. To exert their beneficial effect, microorganisms need to survive the harsh conditions in the upper GI tract, and colonize in the lower intestines and colon, where they support the proliferation of epithelial cells and immune system balance¹.*

The probiotic strains in Supreme Immunity (Lactobacillus acidophilus and Bifidobacterium lactis) have been selected for their natural resilience and ability to survive the hostile environment in the GI tract.

Lactobacillus acidophilus is an extensively studied strain with a documented ability to help promote a healthy immune system, and support bacterial balance in the intestines and colon^5,6,7.* Bifidobacterium lactis is a probiotic bacterium known for its multi-purpose benefits, primarily in supporting digestive and immune system^5,6,8,9.*

The Streptococcus salivarius is a probiotic bacterium considered the first colonizer of the oral cavity and upper respiratory tract. Discovered by Louis Pasteur in 1879, S. salivarius is a spherical, non-spore forming anaerobic organism. It settles in the oral cavity and throat a few hours after birth and plays an important role in the naso-pharynx.

Streptococcus salivarius in Supreme Immunity supports the local factors of immune defense, with primary beneficial effects in the throat, nose and middle ear^10,11.* It produces metabolites called salivaricins, which help maintain a healthy balance of the local microflora^12,13.*

1. FAO/WHO. Vol 85.; 2006. doi:10.1201/9781420009613.ch16
2. Tojo R, Suárez A, Clemente MG, et al. World J Gastroenterol. 2014;20(41):15163-15176. doi:10.3748/wjg.v20.i41.15163
3. AAVV. Fao Who. 2001. doi:10.1201/9781420009613.ch16
4. Sanders ME, Merenstein D, Merrifield CA, Hutkins R. Nutr Bull. 2018;43(3):212-225. doi:10.1111/nbu.12334
5. Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Pediatrics. 2009;124(2):e172-e179. doi:10.1542/peds.2008-2666
6. Gerasimov S V, Ivantsiv VA, Bobryk LM, et al. Eur J Clin Nutr. 2016;70(4):463-469. doi:10.1038/ejcn.2015.171
7. Wheeler JG, Shema SJ, Bogle ML, et al. Ann allergy, asthma Immunol Off Publ Am Coll Allergy, Asthma, Immunol. 1997;79(3):229-233. doi:10.1016/S1081-1206(10)63007-4
8. Meng H, Lee Y, Ba Z, et al. Mol Nutr Food Res. 2016;60(5):1161-1171. doi:10.1002/mnfr.201500665
9. Taipale TJ, Pienihäkkinen K, Isolauri E, Jokela JT, Söderling EM. Pediatr Res. 2016;79(1-1):65-69. doi:10.1038/pr.2015.174
10. Di Pierro F, Colombo M, Zanvit A, Risso P, Rottoli AS. Drug Healthc Patient Saf. 2014;6:15-20. doi:10.2147/DHPS.S59665
11. Kaci G, Goudercourt D, Dennin V, et al. Appl Environ Microbiol. 2014;80(3):928-934. doi:10.1128/AEM.03133-13
12. Dierksen KP, Moore CJ, Inglis M, Wescombe PA, Tagg JR. FEMS Microbiol Ecol. 2007;59(3):584-591. doi:10.1111/j.1574-6941.2006.00228.x
13. Wescombe PA, Upton M, Dierksen KP, et al. Appl Environ Microbiol. 2006;72(2):1459-1466. doi:10.1128/AEM.72.2.1459-1466.2006