Saccharomyces boulardii is a probiotic yeast named after Henri Boulard, the scientist who first isolated it from lychee and mangosteen fruit in 1920.

Clinical studies demonstrate its multiple mechanisms of action and indisputable efficacy and beneficial effects in the GI tract.

S. boulardii is a unique probiotic, with its resistance in digestion. It survives gastric acidity and colonizes the intestinal tract, supporting bifido and lacto bacteria to populate the gut. It helps to balance the composition of intestinal microbiota by producing bacteriocins, with a selective effect on some bacterial species1.* S. boulardii produces polyamines, which support the cells of the intestinal mucosa by secreting digestive enzymes, leading to a pronounced trophic effect. It’s known to support immune function balance and secretion of intestinal immunoglobulin A, which has a key role in the mucosal immunity. It may also help enhance immune defense2.*

Studies have shown that S. boulardii is naturally resistant to antibiotics, since they don’t interfere with its metabolism. It’s a probiotic strain with one of the highest recommendations in the ESPGHAN and WGO guidelines for the use of probiotics3.*

  1. Pais P, Almeida V, Yılmaz M, Teixeira MC. J fungi (Basel, Switzerland). 2020;6(2). doi:10.3390/jof6020078
  2. Stier H, Bischoff SC. Clin Exp Gastroenterol. 2016;9:269-279. doi:10.2147/CEG.S111003
  3. Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H. J Pediatr Gastroenterol Nutr. 2014;59(1):132-152. doi:10.1097/MPG.0000000000000375


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